| 講演要旨： |
Nanophotonic crescents and Biologic Application Specific Inergrated Circuits (BASICs) are developed for quantitative systems biology and molecular preventive medicine. Biocompatible gold-based nanophotonic crescents have structures with a sub-10 nm sharp edge,which can enhance local electromagnetic field at the edge area. Metallic quantum plasmonic nanocrescents are ideal for nanoscale spectroscopic molecular imaging and photothermal therapeutic applicaitions. The formation of asymmetric nanophotonic crescent structure is accomplished for the precise control of surface enhanced Raman scattering (SERS) hot spot coupling nanogap.
Soft-state cellular BASICs are created by connecting existing and novel nano-or micro fluidic circuits for high speed biological and pharmaceutical analysis in new ways. We are creating a library of these “building blocks” to develop multifunctional biochip systems. In order to build a solid foundation of future quantitative biology and systematic bioinformatics for preventive medicine, we are currently establishing critical modules of BASICs such as Intergrated Multiple Patch-clamp Array Chip Technology (IMPACT), multiplexed cell culture chip array, sample preparation chip, cell lysing chip, cell separation, single cell electroporation chip, and cell-cell communication biochip for gap junction studies. The nanocrescent SERS probes and BASICs can be used for sensitive molecular detection, which has enormous benefits inearly disease detection, and drug discovery.
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